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| First Name: | Ruth | | Last Name: | Itzhaki | | Title: | Professor | | Advanced Degrees: | PhD | | Affiliation: | University of Manchester | | Department: | Faculty of Life Sciences, Stopford Building, Room 3.545 | | Street Address 1: | Oxford Road | | City: | Manchester | | State/Province: | Lancs | | Zip/Postal Code: | M13 9PT | Country/Territory: | United Kingdom | | Phone: | 0044 (0)161 306 3879 | | Fax: | 0044 (0)161 275 5762 | | Email Address: |  |
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View all comments by Ruth Itzhaki
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Alzheimer Disease, Prion Diseases, Neurodevelopmental Disorders (Down syndrome, etc.), Aging Process, Parkinson Disease
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Clinical trials, Oxidative Stress, Molecular and Cell biology, Genetics, viruses, Epidemiology, Tau/Cytoskeleton, Brain imaging, DNA microarrays, Animal Models, Neurobiology, Neuroimmunology, A-beta PP/A-beta, Neuropathology
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I was educated at St Paul’s Girls’ School in Hammersmith, where I was a junior and senior Foundation Scholar. I graduated in physics, then worked for an MSc in Biophysics, being awarded one of the only two studentships then available in that subject, and finally proceeded to a PhD in Biophysics - all London University degrees. I then moved to Cambridge, working in the University Department of Radiotherapeutics. I held a Beit Memorial Fellowship for Medical Research and the Wheldale-Onslow Memorial Fellowship (and Praelectorship) at Newnham College. One paper I published in Cambridge became a "citation classic". My next move was to Manchester where I worked initially in the Paterson Laboratories and subsequently in the Department of Optometry and Neuroscience, UMIST. My research topics have been diverse: iron-binding in plasma; effects of ionising radiation on natural and synthetic macromolecules; chromatin structure (I was the first to use polylysine and a nuclease to investigate this); effects of irradiation on chromatin; carcinogens and chromatin; viruses and neurological disease. More recently I have been studying Alzheimer's disease, in particular defective DNA repair, aluminium, and in most detail, the role of viruses in dementia. For the virus work (see Research) I won an Investigator award from the Lancet, a Wellcome Trust Innovative award, and an Olympus Foundation award. I am married; my husband is a scientist, and we have non-identical twin daughters, both scientists. I love music (am an ex-pianist and violinist) - particularly "early" music and that of Bach, Mozart and Brahms, reading, travelling (or rather, arriving), and swimming and snorkeling in warm seas.
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Will fill this in when I have more time. |
Will fill this in when I have more time. |
1. Further work on the role of HSV1 in AD - especially location of the virus in brain, mode of interaction of virus and apoE, effects of HSV1 on APP and tau metabolism, and on oxidative processes.
2. Role of other viruses in various types of dementia 3. Role of APOE in diseases caused by infectious agents, and especially continuation of our relevant work on hepatitis C virus and malaria (v.i.). Basic mechanisms of interaction of apoE and various infectious agents.
4. Molecular/cellular studies on "successful" ageing.
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1. Herpes simplex virus type 1 in brain of carriers of the type 4 allele of the APOE gene confers a strong risk of AD.
2. APOE determines the outcome of infection by various agents, including HSV1 - relating to cold sores and herpes encephalitis, and hepatitis C virus - relating to liver damage, and determines susceptibility to malaria (preliminary data). |
Will fill this in when I have more time |
I do not understand the question |
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